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management:exams:unilateral_rb [Retinoblastoma Wiki]
 

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Developing a "Best Practice Guideline"

Guidelines for ophthalmologic surveillance of children at risk of developing retinoblastoma

Intro

Repeated eye exams are needed for early detection of tumors in children at risk of developing retinoblastoma. In this document we will define the frequency of exams depending on genetic risk and the age of the child (age related risk).

Classification
 1. Genetic risk: defining risk classes
       1. heterozygous for oncogenic germline mutation
       2. heterozygous for germline variant or mutation status unknown
       3. mosaic for germline mutation
       4. germline mutation not detected in peripheral blood DNA
 2. Age related risk (corrected for premature birth)
       1. 0-6 months of life
       2. 6-24 months of life
       3. 24-60 months of life
       4. older
Surveillance

In all children who do not tolerate the necessary manipulations, ophthalmologic exams must be performed under anesthesia. This is generally true for children under 2 years of age (age classes A1 and A2).

Time intervals in children who have not yet developed retinoblastoma

  class G1
        o A1: every 3 weeks
        o A2: every 6 weeks
        o A3:
        o A4
  class G2
        o A1: every 4 weeks
        o A2: every 6-8 weeks
        o A3: every 6-8 weeks
        o A4
 
management/exams/unilateral_rb.txt · Last modified: 2008/11/19 09:22 by dietmar
 
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